Keywords
Acupuncture
Stroke
Antidepressants
Chinese Medicine
Abstract
Introduction. Stroke is one of the leading cerebrovascular diseases and entails significant physical, psychological, and emotional consequences. Among the most common complications is post-stroke depression, a condition that impairs functional and cognitive recovery, reduces quality of life, and increases the risk of mortality. The aim of this review was to evaluate the effectiveness of acupuncture as a non-pharmacological intervention in preventing or reducing depression and anxiety following ischemic stroke.
Materials and Methods. A literature review was conducted through searches of PubMed and CINAHL. Studies published between 2014 and 2024 examining acupuncture for post-stroke depression and anxiety were considered, with particular attention to systematic reviews, randomized controlled trials, and meta-analyses comparing acupuncture with conventional pharmacological treatment or no treatment.
Results. Available literature indicates that acupuncture may be effective in the treatment of post-stroke depression and anxiety and may also promote functional recovery through modulation of neurological, hemodynamic, and metabolic mechanisms. Compared with antidepressant therapy, acupuncture was associated with a favorable safety profile, with mainly mild and transient adverse effects. The availability of different acupuncture techniques may also increase its clinical adaptability.
Discussion. The systemic effects of acupuncture suggest that it may represent a promising complementary option in post-stroke rehabilitation. Appropriately trained nurses may contribute to patient assessment, education, monitoring, and integration of complementary approaches within multidisciplinary care pathways. Further research, shared clinical guidance, and a clear regulatory framework are needed before broader implementation in nursing practice.
References
Chen, B., Zhao, M., Chen, B., Yang, Z., Yu, X., Lin, X., & Fan, C. (2020). Effectiveness and safety of acupuncture in post-stroke depression (PSD): Protocol for a Bayesian analysis. Medicine, 99*(12), e18969. https://doi.org/10.1097/MD.0000000000018969
Hang, X., Li, J., Zhang, Y., Li, Z., Zhang, Y., Ye, X., Tang, Q., & Sun, W. (2021). Efficacy of frequently-used acupuncture methods for specific parts and conventional pharmaceutical interventions in treating post-stroke depression patients: A network meta-analysis. Complementary Therapies in Clinical Practice, 45*, 101471. https://doi.org/10.1016/j.ctcp.2021.101471
Lam Ching, W., Li, H. J., Guo, J., Yao, L., Chau, J., Lo, S., Yuen, C. S., Ng, B. F. L., Yu, E. C.-L., Bian, Z., Lau, A. Y., & Zhong, L. L. D. (2023). Acupuncture for post-stroke depression: A systematic review and network meta-analysis. BMC Psychiatry, 23*, 314. https://doi.org/10.1186/s12888-023-04749-1
Li, P., Zhao, J., Wei, X., Luo, L., Chu, Y., Zhang, T., Zhu, A., & Yan, J. (2024). Acupuncture may play a key role in anti-depression through various mechanisms in depression. Chinese Medicine, 19*, 135. https://doi.org/10.1186/s13020-024-00990-2
Medeiros, G. C., Roy, D., Kontos, N., & Beach, S. R. (2020). Post-stroke depression: A 2020 updated review. General Hospital Psychiatry, 66*, 70–80. https://doi.org/10.1016/j.genhosppsych.2020.06.011
Ministero della Salute. (n.d.). Ictus. Retrieved December 7, 2024, from https://www.salute.gov.it/portale/alleanzaCardioCerebrovascolari/dettaglioSchedeAlleanzaCardioCerebrovascolari.jsp?lingua=italiano&id=28&area=Alleanza%20italiana%20per%20le%20malattie%20cardio-cerebrovascolari&menu=malattie
National Center for Complementary and Integrative Health. (n.d.). Acupuncture: Effectiveness and safety. Retrieved February 14, 2025, from https://www.nccih.nih.gov/health/acupuncture-effectiveness-and-safety
Wang, X., Cai, W., Wang, Y., Huang, S., Zhang, Q., & Wang, F. (2021). Is electroacupuncture an effective and safe treatment for poststroke depression? An updated systematic review and meta-analysis. BioMed Research International, 2021, 8661162. https://doi.org/10.1155/2021/8661162
Wu, L.-K., Hung, C.-S., Kung, Y.-L., Chen, Z.-K., Lin, S.-Z., Lin, J.-G., & Ho, T.-J. (2022). Efficacy of acupuncture treatment for incidence of poststroke comorbidities: A systematic review and meta-analysis of nationalized cohort studies. Evidence-Based Complementary and Alternative Medicine, 2022, 3919866. https://doi.org/10.1155/2022/3919866
Zhang, S.-H., Wang, Y.-L., Zhang, C.-X., Zhang, C.-P., Xiao, P., Li, Q.-F., Liang, W.-R., Pan, X.-H., & Zhou, M.-C. (2022). Effect of interactive dynamic scalp acupuncture on post-stroke cognitive function, depression, and anxiety: A multicenter, randomized, controlled trial. Chinese Journal of Integrative Medicine, 28(2), 106–115. https://doi.org/10.1007/s11655-021-3338-1
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