Vol. 2 No. 1 (2026), Articles
Vol. 2 No. 1 (2026)

Enzymatic Debridement Based Minimally Invasive Modality versus Standard of Care in Modern Burn Management

Articles
Published 2026-03-28
Lior Rosenberg
Department of Plastic Surgery, Soroka University Hospital, Beersheba, Israel; Rosenberg Museum of Medicine, Ben Gurion University of the Negev, Be'er Sheva, Israel
https://orcid.org/0009-0003-0891-5600 (unauthenticated)
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Keywords

Enzymatic Debridement
Minimally Invasive Burn Management
Bromelain-based Debridement
Selective Eschar Removal
Autografting Reduction

How to Cite

Enzymatic Debridement Based Minimally Invasive Modality versus Standard of Care in Modern Burn Management. (2026). International Journal of Wound Research, 2(1), 7-10. https://doi.org/10.64115/ijwr-2026-346
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Abstract

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References

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2. Rosenberg L, Krieger Y, Bogdanov-Berezovski A, Silberstein E, Shoham Y, Singer AJ. A novel rapid and selective enzymatic debridement agent for burn wound management: a multicenter RCT. Burns. 2014;40(3):466-474. https://doi.org/10.1016/j.burns.2013.08.013

3. Shoham Y, Krieger Y, Rubin G, et al. Rapid enzymatic burn debridement: a review of the paediatric clinical trial experience. Int Wound J. 2020;17(5):1337-1345. https://doi.org/10.1111/iwj.13405

4. Shoham Y, Rosenberg L, Narayan RP, et al. Open-label randomized controlled trial of the efficacy and safety of NexoBrid compared to standard of care in children with burns. Burns. 2025;51(4):107417. https://doi.org/10.1016/j.burns.2025.107417

5. Shoham Y, Rosenberg L, Hickerson W, et al. Early enzymatic burn debridement: results of the DETECT multicenter randomized controlled trial. J Burn Care Res. 2024;45(2):297-307. https://doi.org/10.1093/jbcr/irad142

6. Shoham Y, Gasteratos K, Singer AJ, et al. Bromelain-based enzymatic burn debridement: a systematic review of clinical studies on patient safety, efficacy and long-term outcomes. Int Wound J. 2023;20(10):4364-4383. https://doi.org/10.1111/iwj.14308

7. Bowers C, Randawa A, Sloan B, et al. Enzymatic debridement in critically injured burn patients—our experience in the intensive care setting and during burn resuscitation. Burns. 2022;48(4):846-859. https://doi.org/10.1016/j.burns.2021.07.023

8. Hirche C, Citterio A, Hoeksema H, et al. Eschar removal by bromelain-based enzymatic debridement (Nexobrid®) in burns: a European consensus. Burns. 2017;43(8):1640-1653. https://doi.org/10.1016/j.burns.2017.07.025

9. Bloemen MCT, et al. Impact of enzymatic debridement on surgical burden and outcomes in burn care. J Burn Care Res. 2022.

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Copyright (c) 2026 Lior Rosenberg